The Ophidian culture started in the Lands of Danger and Despair shortly after the sundering of the continents after Mondain's defeat at the hands of the Hero. One of the kings of the land, Shamino, was stranded in the Lands of Lord British, and the other, the King of the White Dragon, went insane and killed himself and his subjects.
It was at this time that the Great Serpents contacted the remaining people from the Void. They told the people that if they followed the Great Serpents, they would prosper. The newly named Ophidians quickly built their culture around the Great Serpents and their virtues. They established cities and shrines throughout the renamed Serpent Isle, most of them beneath the huge mountain ranges of Skullcrusher and Spinebreaker, though some were built upon the existing cities. Blackrock was a small, but important part of the Ophidian culture, as it was used in many of the holy items made for use in the shrines, and were imbued with certain magical properties.
The Ophidians were split into three factions, one following the tenets of the Serpent of Order, another following the Serpent of Chaos, and the third following the Great Earth Serpent of Balance. This last group was but few, yet they managed to keep the two opposing philosophies of Chaos and Order at peace with one another, ruled by their respective Hierophants, or leaders, but all being subject to the Great Hierophant of Balance, who in turn communicated the will of the Serpent of Balance.
The Ophidians lived in peace for many years, though the exact length is unknown because of time differences between our Britannia and the Serpent Isle. They had many accomplishments, one being the Serpent Gates, or Dark Path as it was later called. The Serpent Gates allowed instantaneous travel between many of the Ophidian holy places and cities. Another, perhaps the most spectacular of them all, was the Wall of Lights. Three of these magical Walls were made, and they allowed the Hierophants of Chaos, Order, and Balance to enter the Void and commune with their benefactors the Great Serpents.
All of this peace and prosperity was not to last, however, as the Hell-Spawn Exodus, during the Third Age of Darkness, pulled the Great Earth Serpent from the Void in order to protect his castle from assault. The Great Earth Serpent was eventually freed by the Hero, but when he returned he found the Ophidian culture and cities destroyed. During the Great Earth Serpent's long absence, the rival Serpents of Chaos and Order used their followers to wage war against each other in what became the War of Imbalance. During this war, the cities were destroyed and most of the people killed, and eventually Order prevailed. The Chaos Serpent was split into the three Banes, and entrapped by the servants of Order. Having nowhere to live, the remaining servants of Order fled through the Wall of Lights. To where they fled is a mystery, and none but the Order Serpent itself may know. But the Order Serpent's victory was short-lived, as he was alone in the Void, without followers, he went slowly insane. This is what greeted the Serpent of Balance upon his return. The ruins of the Ophidians lay forgotten until the arrival of the settlers, led by Erstam the mage, that fled from Britannia and the rule of Lord British. Yet these people did little to study or preserve the remains of the ancient culture. Upon the arrival of the Avatar, the Hero from Another World, the Ophidian cities and shrines were once again discovered by the Avatar and his Companions. Through the efforts of the Hero from Another World, the Serpents were restored to their place in the Void, yet the Ophidians still lay in their mountain tombs, but their souls now rested in the Void.